Structure of PDB 3f5m Chain A

Receptor sequence
>3f5mA (length=458) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
TSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKKTDYIMYNPRPREN
PVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSITLTG
INVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSR
GPQDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFG
VPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMG
RDSGFIAAQAAVASAQANICLVPENPISEQEVMSLLERRFCHSRSCVIIV
AEGFGQDWGRYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYID
PSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHNNYILVPI
KVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNR
DRLHEELA
3D structure
PDB3f5m The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G107 R173 G174 D199 G200 K226 T227 D229 D231 R274
Catalytic site (residue number reindexed from 1) G84 R150 G151 D176 G177 K203 T204 D206 D208 R251
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G106 G107 Y139 R173 G174 P175 G198 G200 T201 G204 S341 N343 G83 G84 Y116 R150 G151 P152 G175 G177 T178 G181 S314 N316
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042301 phosphate ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0061615 glycolytic process through fructose-6-phosphate
Cellular Component
GO:0005737 cytoplasm
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3f5m, PDBe:3f5m, PDBj:3f5m
PDBsum3f5m
PubMed19084537
UniProtO15648|PFKA_TRYBB ATP-dependent 6-phosphofructokinase (Gene Name=pfk)

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