Structure of PDB 3f4b Chain A

Receptor sequence
>3f4bA (length=284) Species: 5821 (Plasmodium berghei) [Search protein sequence]
NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGK
FDKDMIIKRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVA
NLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLC
KHFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYL
GRKYNIRINTISAGPLKSRAATAINSFIDYAIDYSEKYAPLKKKLLSTDV
GSVASFLLSKESSAVTGQTIYVDNGLNIMFGPDD
3D structure
PDB3f4b The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
ChainA
Resolution2.49 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y262 K270
Catalytic site (residue number reindexed from 1) Y178 K186
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G89 G93 Y94 W114 D153 A154 S200 L201 A202 N203 L250 T251 Y252 K270 A297 P299 L300 S302 A304 G10 G14 Y15 W35 D69 A70 S116 L117 A118 N119 L166 T167 Y168 K186 A213 P215 L216 S218 A220
BS02 TCL A A202 N203 G204 Y252 Y262 A305 I308 A118 N119 G120 Y168 Y178 A221 I224
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3f4b, PDBe:3f4b, PDBj:3f4b
PDBsum3f4b
PubMed19064257
UniProtQ6TEI5

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