Structure of PDB 3f48 Chain A

Receptor sequence
>3f48A (length=509) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
AIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGVPK
GDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILA
VFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLS
LGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFF
GVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSS
IAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFW
AGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYIT
PAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAER
RRNHESAGT
3D structure
PDB3f48 A competitive inhibitor traps LeuT in an open-to-out conformation.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 V23 G24 A351 T354 S355 G16 V19 G20 A345 T348 S349
BS02 NA A A22 V23 N27 T254 N286 A18 V19 N23 T248 N280
BS03 ALA A A22 G24 G26 Y108 F253 T254 S256 A18 G20 G22 Y104 F247 T248 S250 MOAD: Kd=512nM
PDBbind-CN: -logKd/Ki=6.29,Kd=512nM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:3f48, PDBe:3f48, PDBj:3f48
PDBsum3f48
PubMed19074341
UniProtO67854

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