Structure of PDB 3f3t Chain A

Receptor sequence
>3f3tA (length=261) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA
FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGCLLDFLKGEMGK
YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG
LFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL
DQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTS
TEPQYQPGENL
3D structure
PDB3f3t A new screening assay for allosteric inhibitors of cSrc
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D130 R132 A134 N135 D148 F152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1AU A K295 E310 M314 I336 T338 D404 F405 K39 E54 M58 I80 T82 D148 F149 MOAD: Kd=26uM
PDBbind-CN: -logKd/Ki=4.59,Kd=26uM
BindingDB: IC50=6.41e+4nM
BS02 1AU A L273 G274 Q275 G276 Y340 M341 G344 C345 F405 L17 G18 Q19 G20 Y84 M85 G88 C89 F149 MOAD: Kd=26uM
PDBbind-CN: -logKd/Ki=4.59,Kd=26uM
BindingDB: IC50=6.41e+4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3f3t, PDBe:3f3t, PDBj:3f3t
PDBsum3f3t
PubMed19396179
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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