Structure of PDB 3f1r Chain A

Receptor sequence
>3f1rA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
PGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFI
SVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTY
SSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVP
ELYKDLL
3D structure
PDB3f1r Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R140 R164 R89 R113
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005104 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0043395 heparan sulfate proteoglycan binding
GO:0090722 receptor-receptor interaction
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0014059 regulation of dopamine secretion
GO:0030154 cell differentiation
GO:0030334 regulation of cell migration
GO:0042491 inner ear auditory receptor cell differentiation
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1904340 positive regulation of dopaminergic neuron differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3f1r, PDBe:3f1r, PDBj:3f1r
PDBsum3f1r
PubMed19564416
UniProtQ9NP95|FGF20_HUMAN Fibroblast growth factor 20 (Gene Name=FGF20)

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