Structure of PDB 3eyd Chain A

Receptor sequence

>3eydA (length=181) [Search protein sequence]

APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS

3D structure

PDB

3eyd Potent inhibitors of HCV-NS3 protease derived from boronic acids.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H57 D81 G137 S139
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	P2 T4 A5 Y6 A7 Q8 Q9 T10 R11 C16 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65	P2 T4 A5 Y6 A7 Q8 Q9 T10 R11 C16 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65
BS02	peptide	A	T4 A5 Y6 A7 Q8	T4 A5 Y6 A7 Q8
BS03	ZN	A	C97 C99 C145	C97 C99 C145
BS04	BE8	A	H57 R123 G137 S139 F154 R155 A156 A157 V158 C159	H57 R123 G137 S139 F154 R155 A156 A157 V158 C159	PDBbind-CN: -logKd/Ki=9.70,Ki=0.2nM

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3eyd, PDBe:3eyd, PDBj:3eyd
PDBsum	3eyd
PubMed	19022670
UniProt	P26664\|POLG_HCV1 Genome polyprotein

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