Structure of PDB 3ewc Chain A

Receptor sequence
>3ewcA (length=357) Species: 5855 (Plasmodium vivax) [Search protein sequence]
PIDFLKKEELKNIDLSQMSKKERYKIWKRIPKCELHCHLDLCFSADFFVS
CIRKYNLQPNLSDEEVLDYYLFAKGGKSLGEFVEKAIKVADIFHDYEVIE
DLAKHAVFNKYKEGVVLMEFRYSPTFVAFKYNLDIELIHQAIVKGIKEVV
ELLDHKIHVALMCIGDTGHEAANIKASADFCLKHKADFVGFDHGGHEVDL
KEYKEIFDYVRESGVPLSVHAGEDVTLPNLNTLYSAIQVLKVERIGHGIR
VAESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGVKVS
VNSDDPGMFLTNINDDYEELYTHLNFTLEDFMKMNEWALEKSFMDSNIKD
KIKNLYF
3D structure
PDB3ewc Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H42 H44 H226 E229 H253 D310
Catalytic site (residue number reindexed from 1) H36 H38 H220 E223 H247 D304
Enzyme Commision number 3.5.4.31: S-methyl-5'-thioadenosine deaminase.
3.5.4.4: adenosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H42 H44 H226 D310 H36 H38 H220 D304
BS02 MCF A H44 L85 F88 D172 T173 G174 H175 G201 H226 E229 H253 D310 D311 H38 L79 F82 D166 T167 G168 H169 G195 H220 E223 H247 D304 D305 MOAD: Ki=20nM
PDBbind-CN: -logKd/Ki=7.70,Ki=20nM
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0019239 deaminase activity
GO:0046872 metal ion binding
GO:0046936 2'-deoxyadenosine deaminase activity
GO:0090614 5'-methylthioadenosine deaminase activity
Biological Process
GO:0006154 adenosine catabolic process
GO:0006166 purine ribonucleoside salvage
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0043103 hypoxanthine salvage
GO:0046103 inosine biosynthetic process
GO:0060169 negative regulation of adenosine receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0009897 external side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ewc, PDBe:3ewc, PDBj:3ewc
PDBsum3ewc
PubMed19728741
UniProtA5KE01|ADA_PLAVS Adenosine deaminase (Gene Name=ADA)

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