Structure of PDB 3euz Chain A

Receptor sequence

>3euzA (length=119) Species: 9913 (Bos taurus)

ETAAAKFERQHMDSSSSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQ
AVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKH
IIVACEGNPYVPVHFDASV

3D structure

• PDB: 3euz Multiple solvent crystal structures of ribonuclease A: An assessment of the method
• Chain: A
• Resolution: 1.84 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41 H119 F120 D121
• Catalytic site (residue number reindexed from 1): H11 K36 H114 F115 D116
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DMF	A	N62 V63 A64 T70	N57 V58 A59 T65

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:3euz, PDBe:3euz, PDBj:3euz
• PDBsum: 3euz
• PubMed: 19291738
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)