Structure of PDB 3eth Chain A

Receptor sequence
>3ethA (length=355) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI
ERWPETALTRQLARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL
AERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGEC
IVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA
QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWT
QNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLV
HLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWA
QSKFG
3D structure
PDB3eth Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y126 G128 E226 E238 N245 S246 K314
Catalytic site (residue number reindexed from 1) Y126 G128 E226 E238 N245 S246 K314
Enzyme Commision number 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A R80 I118 K120 Y126 D127 G128 Q131 I156 F158 E161 H184 E226 F228 N237 E238 R80 I118 K120 Y126 D127 G128 Q131 I156 F158 E161 H184 E226 F228 N237 E238
BS02 MG A E226 E238 E226 E238
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3eth, PDBe:3eth, PDBj:3eth
PDBsum3eth
PubMed19053251
UniProtP09029|PURK_ECOLI N5-carboxyaminoimidazole ribonucleotide synthase (Gene Name=purK)

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