Structure of PDB 3et3 Chain A

Receptor sequence
>3et3A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
MESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
3D structure
PDB3et3 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 N312 V315 T316 L318 K319 P467 L468 E471 K84 N95 V98 T99 L101 K102 P250 L251 E254
BS02 ET1 A F282 C285 S289 H323 F363 M364 K367 H449 L469 Y473 F65 C68 S72 H106 F146 M147 K150 H232 L252 Y256
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3et3, PDBe:3et3, PDBj:3et3
PDBsum3et3
PubMed19116277
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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