Structure of PDB 3et2 Chain A

Receptor sequence
>3et2A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
VADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQ
AEKGLVWVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLF
LNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPF
SDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQ
DTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTE
TETSLHPLLQEIYKDM
3D structure
PDB3et2 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ET1 A F246 C249 T253 H287 L294 I327 H413 M417 L433 Y437 F72 C75 T79 H113 L120 I153 H239 M243 L259 Y263
BS02 1BO A L219 W220 L48 W49
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3et2, PDBe:3et2, PDBj:3et2
PDBsum3et2
PubMed19116277
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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