Structure of PDB 3et1 Chain A

Receptor sequence
>3et1A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLC
MAEKTLVAQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQ
VTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIM
EPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIV
HVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAA
LHPLLQEIYRDMY
3D structure
PDB3et1 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K292 L302 N303 Q305 L309 K310 P458 L459 E462 R465 K87 L97 N98 Q100 L104 K105 P253 L254 E257 R260
BS02 ET1 A F273 C276 Q277 T279 S280 Y314 I354 M355 Y464 F68 C71 Q72 T74 S75 Y109 I149 M150 Y259
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3et1, PDBe:3et1, PDBj:3et1
PDBsum3et1
PubMed19116277
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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