Structure of PDB 3ert Chain A

Receptor sequence
>3ertA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA
QLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHA
3D structure
PDB3ert The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT A M343 L346 A350 E353 W383 M421 G521 L525 H550 A551 M38 L41 A45 E48 W78 M116 G216 L220 H245 A246 PDBbind-CN: -logKd/Ki=9.60,Ki=0.249nM
BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
External links
PDB RCSB:3ert, PDBe:3ert, PDBj:3ert
PDBsum3ert
PubMed9875847
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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