Structure of PDB 3erd Chain A

Receptor sequence
>3erdA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL
3D structure
PDB3erd The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 D538 E542 M543 I54 K58 L68 V72 E76 D234 E238 M239
BS02 DES A M343 E353 L387 M421 H524 L525 M39 E49 L83 M117 H220 L221 PDBbind-CN: -logKd/Ki=9.90,Ki=0.126nM
BindingDB: Ki=0.128000nM,IC50=0.330000nM,EC50=0.110000nM
External links
PDB RCSB:3erd, PDBe:3erd, PDBj:3erd
PDBsum3erd
PubMed9875847
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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