Structure of PDB 3eq7 Chain A

Receptor sequence
>3eq7A (length=707) Species: 9823 (Sus scrofa) [Search protein sequence]
FQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPF
LEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQ
DSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTI
KFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETS
TNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIRE
GCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFK
TNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCY
LHDVKNTLQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLS
PGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMF
IVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVAN
IRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGG
SNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSD
SKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFI
ATLQYIVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARC
LNIDWIP
3D structure
PDB3eq7 Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
ChainA
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y473 S554 D641 H680
Catalytic site (residue number reindexed from 1) Y470 S551 D638 H677
Enzyme Commision number 3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X99 A F173 C255 F476 S554 W595 R643 F170 C252 F473 S551 W592 R640 PDBbind-CN: -logKd/Ki=9.09,IC50=0.81nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3eq7, PDBe:3eq7, PDBj:3eq7
PDBsum3eq7
PubMed19006380
UniProtP23687|PPCE_PIG Prolyl endopeptidase (Gene Name=PREP)

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