Structure of PDB 3eq6 Chain A

Receptor sequence
>3eq6A (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]
HQEVPAKFNFASDVLDHWADMEKAGKRPPSPALWWVNGKGKELMWNFREL
SENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPG
TIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEK
SCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYS
SLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVH
LLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVT
VGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTA
ASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAAN
IRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMEHP
AVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQHVKSVTA
PYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWK
3D structure
PDB3eq6 Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T221 T364 E365 N467 R472 K557
Catalytic site (residue number reindexed from 1) T185 T328 E329 N431 R436 K521
Enzyme Commision number 6.2.1.2: medium-chain acyl-CoA ligase.
6.2.1.25: benzoate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G338 E339 S340 E359 S360 Y361 G362 Q363 T364 D446 F458 R461 R472 G302 E303 S304 E323 S324 Y325 G326 Q327 T328 D410 F422 R425 R436
BS02 BCO A W265 F291 I313 V337 S469 G470 Y471 P537 Y538 Y540 R542 W229 F255 I277 V301 S433 G434 Y435 P501 Y502 Y504 R506
Gene Ontology
Molecular Function
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0016874 ligase activity
GO:0018858 benzoate-CoA ligase activity
GO:0031956 medium-chain fatty acid-CoA ligase activity
GO:0046872 metal ion binding
GO:0102391 decanoate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0036112 medium-chain fatty-acyl-CoA metabolic process
GO:0042593 glucose homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3eq6, PDBe:3eq6, PDBj:3eq6
PDBsum3eq6
PubMed19345228
UniProtQ08AH3|ACS2A_HUMAN Acyl-coenzyme A synthetase ACSM2A, mitochondrial (Gene Name=ACSM2A)

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