Structure of PDB 3eq1 Chain A

Receptor sequence
>3eq1A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAFTKELEHALEKNE
VDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPE
KSVVGTSSLRRAAQLQRKFPHLEFRSIQGNLNTRLRKLDEQQEFSAIILA
TAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLH
DPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSD
SIQETMQATIHVPQHEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLS
KGAKNILDVARQ
3D structure
PDB3eq1 Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K98 D99 R149 R150 Q167 R173 C261
Catalytic site (residue number reindexed from 1) K59 D60 R110 R111 Q128 R134 C222
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DPM A S96 K98 D99 S146 S147 R149 R150 R173 L188 A189 C261 S57 K59 D60 S107 S108 R110 R111 R134 L149 A150 C222
BS02 SO4 A R26 S28 R8 S10
BS03 SO4 A H120 P208 H268 H81 P169 H229
BS04 SO4 A P119 R246 P80 R207
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3eq1, PDBe:3eq1, PDBj:3eq1
PDBsum3eq1
PubMed19207107
UniProtP08397|HEM3_HUMAN Porphobilinogen deaminase (Gene Name=HMBS)

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