Structure of PDB 3epz Chain A

Receptor sequence
>3epzA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
GPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDALPQHKLTC
FSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIPGGVNGKNLGPINEWWI
TGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSN
SDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGD
QPIFLTPCMRDLIKLAGVTLGQRRAQA
3D structure
PDB3epz The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C353 C356 C414 H418 C4 C7 C55 H59
BS02 BGC A W465 I466 E485 W99 I100 E116
External links
PDB RCSB:3epz, PDBe:3epz, PDBj:3epz
PDBsum3epz
PubMed21389349
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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