Structure of PDB 3eps Chain A

Receptor sequence

>3epsA (length=566) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]

PRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRI
HLYDHHVGLVVEQLRCITNGQSTDAEFLLRVKEHYTRLLPDYPRFEIAES
FFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWES
LLMRVISDLPLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANELF
YRNKAAWLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFG
FARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREY
LVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSAA
HVRACYQLVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKI
TDLGEQIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAA
NIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPPWYSV
SPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVE
DVYAYRRRQRFSVRYG

3D structure

PDB

3eps Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AMP	A	N104 S105 H113 K291 K294 T295 Y298 F375 E376 N377	N103 S104 H112 K290 K293 T294 Y297 F374 E375 N376
BS02	ATP	A	P316 I318 V322 M323 V325 K336 E416 R417 R418 M419 P421 Y474 D475 D477 E478	P315 I317 V321 M322 V324 K335 E415 R416 R417 M418 P420 Y473 D474 D476 E477
BS03	MG	A	N462 D475	N461 D474

Gene Ontology

	Molecular Function
GO:0004674	protein serine/threonine kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005524	ATP binding
GO:0008772	[isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208	AMP binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016791	phosphatase activity

	Biological Process
GO:0006006	glucose metabolic process
GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006470	protein dephosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0050790	regulation of catalytic activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3eps, PDBe:3eps, PDBj:3eps
PDBsum	3eps
PubMed	20505668
UniProt	Q8X607\|ACEK_ECO57 Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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