Structure of PDB 3epm Chain A

Receptor sequence
>3epmA (length=515) Species: 155892 (Caulobacter vibrioides) [Search protein sequence]
TISTGPIPGSRKVYQAGELFPELRVPFREVAVHPSANEPPVTIYDPSGPY
SDPAIQIDIEKGLPRTREALVVARGDVEEVADPRQAPEFPDTGRKIYRAK
PGKLVTQLEYARAGIITAEMEYVAIRENLRREQDRPCVRDGEDFGASIPD
FVTPEFVRQEIARGRAIIPANINHGELEPMAIGRNFLVKINANIGNTVAD
EVDKLVWATRWGADTVMDLSTGRNIHNIRDWIIRNSSVPIGTVPIYQALE
KVNGVAEDLNWEVFRDTLIEQCEQGVDYFTIHAGVRLPFIPMTAKRVTGI
VSRGGSIMAKWCLAHHKENFLYERFDEICEIMRAYDVSFSLGDGLRPGST
ADANDEAQFSELRTLGELTKVAWKHGVQVMIEGPGHVAMHKIKANMDEQL
KHCHEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEH
LGLPDRDDVKTGVITYKLAAHAADLAKGHPGAAMWDDAISRARFEFRWED
QFNLGLDPETARKFH
3D structure
PDB3epm Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
ChainA
Resolution2.793 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.99.17: phosphomethylpyrimidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H417 H481 H386 H450
BS02 HMH A H313 S333 R334 H282 S302 R303
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0070284 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
Biological Process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3epm, PDBe:3epm, PDBj:3epm
PDBsum3epm
PubMed18953358
UniProtQ9A6Q5|THIC_CAUVC Phosphomethylpyrimidine synthase (Gene Name=thiC)

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