Structure of PDB 3epg Chain A

Receptor sequence
>3epgA (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSYGRESRQCPIPSHVIQKDVMTPMV
DILMKLFRNMVNVLTLLSVCFCNLK
3D structure
PDB3epg Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E127 K207 G241 G243 T246 E358 S359 R360 Q361 E103 K183 G217 G219 T222 E330 S331 R332 Q333
BS02 dna A Q59 L78 E97 L99 P299 Q300 S303 E304 E305 S307 Q35 L54 E73 L75 P275 Q276 S279 E280 E281 S283
BS03 DCP A L35 C37 Y39 V64 T65 Y68 R71 D126 L11 C13 Y15 V40 T41 Y44 R47 D102
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3epg, PDBe:3epg, PDBj:3epg
PDBsum3epg
PubMed18984581
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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