Structure of PDB 3epb Chain A

Receptor sequence
>3epbA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFM
KPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPPDQ
TLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNP
CGYSMNGMKSDGTYWTIHITPEPEFSYVSFQTNLSQTSYDDLIRKVVEVF
KPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSF
AKK
3D structure
PDB3epb Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S229 H243
Catalytic site (residue number reindexed from 1) S154 H168
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PUT A F111 T176 F285 F43 T101 F210
BS02 PYR A S69 K80 S1 K12
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0006597 spermine biosynthetic process
GO:0008295 spermidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3epb, PDBe:3epb, PDBj:3epb
PDBsum3epb
PubMed19053272
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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