Structure of PDB 3emd Chain A

Receptor sequence
>3emdA (length=259) Species: 164416 (Wesselsbron virus) [Search protein sequence]
VTLGEVWKRQLNMLGKQEFERYKVSDITEVDRTAARRYLKEGRTDVGISV
SRGAAKIRWLHERGYLRITGRVLDLGCGRGGWSYYAAAQKEVMSVKGYTL
GIEGHEKPIHMQTLGWNIVKFKDKSNVFTMPTEPSDTLLCDIGESSSNPL
VERDRTMKVLENFERWKHVNTENFCVKVLAPYHPDVIEKLERLQLRFGGG
IVRVPFSRNSTHEMYYISGARNNITHMVNTTSRSLLRRMTRPSGKAIIEG
DVFLPTGTR
3D structure
PDB3emd Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A S56 G58 G81 G86 W87 T104 L105 E111 S130 N131 V132 F133 D146 I147 S51 G53 G76 G81 W82 T99 L100 E106 S125 N126 V127 F128 D141 I142
BS02 GTA A K13 L16 N17 L19 K21 F24 S151 S152 S215 K8 L11 N12 L14 K16 F19 S146 S147 S210
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3emd, PDBe:3emd, PDBj:3emd
PDBsum3emd
PubMed18976670
UniProtD0VX01

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