Structure of PDB 3el7 Chain A

Receptor sequence
>3el7A (length=254) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGGEVWMGTWNGTTRVAIKTLKPTMSPEAFLQ
EAQVMKKLRHEKLVQLYAVVSEIYIVTEYMSKGSLLDFLKGEMGKYLRLP
QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGPIKWT
APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY
RMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQP
GENL
3D structure
PDB3el7 Small molecule recognition of c-Src via the Imatinib-binding conformation.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D125 R127 A129 N130 D143
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PD3 A A293 K295 E310 M314 Y340 M341 L393 V402 A403 D404 A35 K37 E51 M55 Y79 M80 L132 V141 A142 D143 PDBbind-CN: -logKd/Ki=6.32,IC50=0.48uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3el7, PDBe:3el7, PDBj:3el7
PDBsum3el7
PubMed18940662
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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