Structure of PDB 3el3 Chain A

Receptor sequence
>3el3A (length=417) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
REPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVT
NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQP
AFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLL
RGQYMDERAERLCVALATVFRGLPANRRFNDALADLHLLVDEIIAERRAS
GQKPDDLLTALLEAGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPE
HADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRA
VAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV
PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV
GITLRPHDLLVRPVARH
3D structure
PDB3el3 Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T278 F403 C410
Catalytic site (residue number reindexed from 1) T233 F358 C365
Enzyme Commision number 1.14.15.39: epi-isozizaene 5-monooxygenase.
4.2.3.47: beta-farnesene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A I271 G275 T278 I279 T282 R343 P402 F403 R408 C410 S412 S416 I226 G230 T233 I234 T237 R298 P357 F358 R363 C365 S367 S371
BS02 EL3 A W92 P274 V338 I447 W71 P229 V293 I402
BS03 EL3 A L91 W339 L70 W294
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0010333 terpene synthase activity
GO:0010334 sesquiterpene synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0042181 ketone biosynthetic process
GO:0051762 sesquiterpene biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3el3, PDBe:3el3, PDBj:3el3
PDBsum3el3
PubMed19858213
UniProtQ9K498|EIZFM_STRCO Bifunctional albaflavenone monooxygenase/terpene synthase (Gene Name=SCO5223)

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