Structure of PDB 3efk Chain A

Receptor sequence
>3efkA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP
LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR
DLAARNCMLDEKFTVKVADFPVKWMALESLQTQKFTTKSDVWSFGVLLWE
LMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAE
MRPSFSELVSRISAIFSTFIGEHYVH
3D structure
PDB3efk Design, synthesis, and biological evaluation of potent c-Met inhibitors.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D151 A153 R155 N156 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MT4 A I1084 F1089 A1108 F1124 E1127 G1128 M1131 L1140 L1142 L1157 Y1159 M1160 G1163 M1211 D1222 F1223 I31 F36 A55 F71 E74 G75 M78 L87 L89 L104 Y106 M107 G110 M158 D169 F170 MOAD: Ki=14nM
PDBbind-CN: -logKd/Ki=7.85,Ki=14nM
BindingDB: Ki=14nM,IC50=14nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3efk, PDBe:3efk, PDBj:3efk
PDBsum3efk
PubMed18763753
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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