Structure of PDB 3edy Chain A

Receptor sequence
>3edyA (length=544) Species: 9606 (Homo sapiens) [Search protein sequence]
SYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVS
DPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDF
LTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDF
VGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSG
TSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRA
GIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPH
VHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVS
GRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRP
SYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIP
WVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVT
RGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
3D structure
PDB3edy Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.9: tripeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D517 V518 G539 G541 D543 D498 V499 G520 G522 D524
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008240 tripeptidyl-peptidase activity
GO:0035727 lysophosphatidic acid binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0120146 sulfatide binding
Biological Process
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0007040 lysosome organization
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0030163 protein catabolic process
GO:0030855 epithelial cell differentiation
GO:0043171 peptide catabolic process
GO:0045453 bone resorption
GO:0050885 neuromuscular process controlling balance
GO:0070198 protein localization to chromosome, telomeric region
GO:1905146 lysosomal protein catabolic process
Cellular Component
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0042470 melanosome
GO:0043202 lysosomal lumen
GO:0045121 membrane raft
GO:0055037 recycling endosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3edy, PDBe:3edy, PDBj:3edy
PDBsum3edy
PubMed19038967
UniProtO14773|TPP1_HUMAN Tripeptidyl-peptidase 1 (Gene Name=TPP1)

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