Structure of PDB 3ebz Chain A

Receptor sequence
>3ebzA (length=99) Species: 11720 (Human immunodeficiency virus type 2 (ISOLATE ROD)) [Search protein sequence]
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGI
GGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
3D structure
PDB3ebz Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMD A Y14 E65 Y14 E65
BS02 017 A D25 A28 D30 I32 I82 I84 D25 A28 D30 I32 I82 I84
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ebz, PDBe:3ebz, PDBj:3ebz
PDBsum3ebz
PubMed18834890
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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