Structure of PDB 3e90 Chain A

Receptor sequence
>3e90A (length=47) Species: 11082 (West Nile virus) [Search protein sequence]
DMWIERTADISWESDAEITGSSERVDVRLDDDGNFQLMNDPGAGGGG
3D structure
PDB3e90 Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKK A G83 F85 Q86 G33 F35 Q36 PDBbind-CN: -logKd/Ki=7.39,Ki=41nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:3e90, PDBe:3e90, PDBj:3e90
PDBsum3e90
PubMed19059417
UniProtP06935|POLG_WNV Genome polyprotein

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