Structure of PDB 3e7o Chain A

Receptor sequence
>3e7oA (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLS
RPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM
ELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGYKENVDI
WSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRN
YVENRPAYPGIAFEELFPDWIFPSERDKIKTSQARDLLSKMLVIDPDKRI
SVDEALRHPYITVWYDPAEAEAPPPQIHAIEEWKELIYKEVM
3D structure
PDB3e7o The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 T180
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 35F A I32 V40 A53 M108 E109 L110 M111 D112 A113 L168 I24 V32 A45 M100 E101 L102 M103 D104 A105 L160 MOAD: ic50=120nM
PDBbind-CN: -logKd/Ki=6.92,IC50=120nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3e7o, PDBe:3e7o, PDBj:3e7o
PDBsum3e7o
PubMed18801372
UniProtP45984|MK09_HUMAN Mitogen-activated protein kinase 9 (Gene Name=MAPK9)

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