Structure of PDB 3e7j Chain A

Receptor sequence
>3e7jA (length=743) Species: 984 (Pedobacter heparinus) [Search protein sequence]
DVVWKDVDGVSMPIPPKTHPRLYLREQQVPDLKNRMNDPKLKKVWADMIK
MQEDWKPADIPEVKDFRFYFNQKGLTVRVELMALNYLMTKDPKVGREAIT
SIIDTLETATFKPAGDISRGIGLFMVTGAIVYDWCYDQLKPEEKTRFVKA
FVRLAKMLECGYPPVKDKSIVGAASEWMIMRDLLSVGIAIYDEFPEMYNL
AAGRFFKEHLVARNWFYPSHNYHQGMSALNVRFTNDLFALWILDRMGAGN
VFNPGQQFILYDAIYKRRPDGQILAGGDVDYSRKKPKYYTMPALLAGSYY
KDEYLNYEFLKDPNVEPHCKLFEFLWRDTQLGSRKPDDLPLSRYSGSPFG
WMIARTGWGPESVIAEMKVNEYSFLNHQHQDAGAFQIYYKGPLAIDAGSY
TGSSGGYNSPHNKNFFKRTIAHNSLLIYDPKETFSSSGYGGSDHTDFAAN
DGGQRLPGKGWIAPRDLKEMLAGDFRTGKILAQGFGPDNQTPDYTYLKGD
ITAAYSAKVKEVKRSFLFLNLKDAKVPAAMIVFDKVVASNPDFKKFWLLH
SIEQPEIKGNQITIKRTKNGDSGMLVNTALLPDAANSNITSIGGKGKDFW
VFGTNYTNDPKPGTDEALERGEWRVEITPKKAAAEDYYLNVIQIADNTQQ
KLHEVKRIDGDKVVGVQLADRIVTFSKTSETVDRPFGFSVVGKGTFKFVM
TDLLPGTWQVLKDGKILYPALSAKGDDGALYFEGTEGTYRFLR
3D structure
PDB3e7j Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.2.7: heparin lyase.
4.2.2.8: heparin-sulfate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GCU A D145 H406 Y429 D116 H377 Y400
BS02 ZN A H408 D425 H451 H379 D396 H422
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3e7j, PDBe:3e7j, PDBj:3e7j
PDBsum3e7j
PubMed20404324
UniProtC6XZB6|HEPB_PEDHD Heparin and heparin-sulfate lyase (Gene Name=hepB)

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