Structure of PDB 3e7f Chain A

Receptor sequence
>3e7fA (length=260) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
SFKPTISVHATPQELSAAGCRKIVEIIEASGSQQWPLSIALAGGSTPKMT
YARLHDEHLNLLREKRALRFFMGDERMVPADSTDSNYNMAREVLLHDIPD
DLVFPFDTSAVTPSAEATSADAMRVAEAYGKQLASLLPLKSVGEAGPKVP
VFDVVLLGLGSDGHTASIFPGSQAEKETDGKVVVSVGFPSETMKPKVWRV
TLSPATIMQARNVIVLATGAEKKWVVDGILADTAHKAPVARFLRGCEGNV
SFLLDKEIAE
3D structure
PDB3e7f Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.31: 6-phosphogluconolactonase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H56 H97 D98 H55 H96 D97
BS02 6PG A S46 R77 H165 M194 K195 R200 K223 S45 R76 H164 M193 K194 R199 K222 BindingDB: Kd=10000nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0017057 6-phosphogluconolactonase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
Cellular Component
GO:0005737 cytoplasm
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e7f, PDBe:3e7f, PDBj:3e7f
PDBsum3e7f
PubMed19345229
UniProtQ9GRG6

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