Structure of PDB 3e7c Chain A

Receptor sequence
>3e7cA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQNLLCFAPDLI
INEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKD
GLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEV
VENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3e7c The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 D590 M593 M752 E755 V50 K54 L64 D65 M68 M224 E227
BS02 866 A L563 N564 G567 Q570 M604 A607 R611 F623 Q642 Y735 C736 L753 L38 N39 G42 Q45 M79 A82 R86 F95 Q114 Y207 C208 L225 BindingDB: EC50=2nM,IC50=3.16nM
External links
PDB RCSB:3e7c, PDBe:3e7c, PDBj:3e7c
PDBsum3e7c
PubMed18952422
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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