Structure of PDB 3e3f Chain A

Receptor sequence
>3e3fA (length=182) Species: 727 (Haemophilus influenzae) [Search protein sequence]
TPHYLWIGCSDSRAPAEKLTNLEPGELFVHRNVANQVIHTDFNCLSVVQY
AVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWLLHIRDIWFKHGHL
LGKLSPEKRADMLTKINVAEQVYNLGRTSIVKSAWERGQKLSLHGWVYDV
NDGFLVDQGVMATSRETLEISYRNAIARLSIL
3D structure
PDB3e3f Evidence for a bicarbonate "escort" site in Haemophilus influenzae beta-carbonic anhydrase .
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C42 D44 R46 H98 C101
Catalytic site (residue number reindexed from 1) C9 D11 R13 H65 C68
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C42 D44 H98 C101 C9 D11 H65 C68
BS02 BCT A P48 A49 E50 R64 P15 A16 E17 R31
BS03 BCT A W39 S45 A47 L52 R64 W6 S12 A14 L19 R31
BS04 BCT A R160 K165 R198 R127 K132 R165
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0015976 carbon utilization
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e3f, PDBe:3e3f, PDBj:3e3f
PDBsum3e3f
PubMed20359198
UniProtP45148|CAN_HAEIN Carbonic anhydrase 2 (Gene Name=can)

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