Structure of PDB 3e1y Chain A

Receptor sequence
>3e1yA (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
AADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEF
GTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGK
EKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGA
LFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVA
ETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDI
SYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRLYLTPEQMPLLEWFANNYKKFGATLE
IVTDKSQEGSQFVKGFGGIGGILRYRVDFQ
3D structure
PDB3e1y Structural insights into eRF3 and stop codon recognition by eRF1
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K118 N121 K112 N115
BS02 ATP A T58 A59 I62 T52 A53 I56
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0005515 protein binding
GO:0008079 translation termination factor activity
GO:0016149 translation release factor activity, codon specific
GO:0043022 ribosome binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:0006479 protein methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e1y, PDBe:3e1y, PDBj:3e1y
PDBsum3e1y
PubMed19417105
UniProtP62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)

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