Structure of PDB 3e0l Chain A

Receptor sequence
>3e0lA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
PLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKE
WCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYT
FPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADIT
DKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVK
PIVTPGNGVSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYK
NYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLS
SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVN
EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPI
DLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFS
3D structure
PDB3e0l Alteration of enzyme specificity by computational loop remodeling and design.
ChainA
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.3: guanine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H82 H84 H238 D328 H75 H77 H231 D321
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0000255 allantoin metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006147 guanine catabolic process
GO:0006161 deoxyguanosine catabolic process
GO:0007399 nervous system development
GO:0043605 amide catabolic process
GO:0046038 GMP catabolic process
GO:0046055 dGMP catabolic process
GO:0046098 guanine metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e0l, PDBe:3e0l, PDBj:3e0l
PDBsum3e0l
PubMed19470646
UniProtQ9Y2T3|GUAD_HUMAN Guanine deaminase (Gene Name=GDA)

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