Structure of PDB 3dzy Chain A

Receptor sequence
>3dzyA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK
RQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMP
VERILEAELAPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRA
GWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTEL
VSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAY
CKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLME
ML
3D structure
PDB3dzy Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001972 retinoic acid binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0004879 nuclear receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042277 peptide binding
GO:0042802 identical protein binding
GO:0042809 nuclear vitamin D receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0046872 metal ion binding
GO:0050692 DNA binding domain binding
GO:0050693 LBD domain binding
GO:0070644 vitamin D response element binding
GO:1990837 sequence-specific double-stranded DNA binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002157 positive regulation of thyroid hormone receptor signaling pathway
GO:0006355 regulation of DNA-templated transcription
GO:0009755 hormone-mediated signaling pathway
GO:0010875 positive regulation of cholesterol efflux
GO:0030154 cell differentiation
GO:0030501 positive regulation of bone mineralization
GO:0032411 positive regulation of transporter activity
GO:0032526 response to retinoic acid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042789 mRNA transcription by RNA polymerase II
GO:0043401 steroid hormone receptor signaling pathway
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048384 retinoic acid receptor signaling pathway
GO:0070564 positive regulation of vitamin D receptor signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043235 receptor complex
GO:0090575 RNA polymerase II transcription regulator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3dzy, PDBe:3dzy, PDBj:3dzy
PDBsum3dzy
PubMed19043829
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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