Structure of PDB 3dz4 Chain A

Receptor sequence
>3dz4A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
cSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNF
MKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFSQP
DQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMF
NPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVE
VFKPGKFVTTLFVNQSSKCRKIEGFKRLDCQSAMFNDYNFVFTSFAK
3D structure
PDB3dz4 New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S229 H243
Catalytic site (residue number reindexed from 1) S155 H169
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C8M A X68 C82 F223 N224 C226 G227 S229 I244 T245 E247 X1 C15 F150 N151 C153 G154 S156 I171 T172 E174 MOAD: ic50=400nM
PDBbind-CN: -logKd/Ki=6.40,IC50=400nM
BindingDB: IC50=400nM
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0006597 spermine biosynthetic process
GO:0008295 spermidine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3dz4, PDBe:3dz4, PDBj:3dz4
PDBsum3dz4
PubMed19209891
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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