Structure of PDB 3dys Chain A

Receptor sequence
>3dysA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
TYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSIN
PVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD
ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQ
ILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN
FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDRE
KSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQ
PLWESRDRYEELKRIDDAMKELQK
3D structure
PDB3dys Structural basis for the catalytic mechanism of human phosphodiesterase 9.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H256 H292 D293 D402 H75 H111 D112 D221
BS02 MN A D244 Y246 D63 Y65
BS03 5GP A H252 H292 D293 M365 D402 I403 L420 Y424 Q453 F456 H71 H111 D112 M184 D221 I222 L239 Y243 Q272 F275
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3dys, PDBe:3dys, PDBj:3dys
PDBsum3dys
PubMed18757755
UniProtO76083|PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Gene Name=PDE9A)

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