Structure of PDB 3dy7 Chain A

Receptor sequence
>3dy7A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI
IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI
PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV
SGQLIDSMANGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP
PPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ
LMVHAFIKRS
3D structure
PDB3dy7 Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 S194 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1) D129 K131 S133 N134 D147 D156 T162
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N195 D208 N134 D147
BS02 ATP A L74 G75 N78 A95 K97 M143 E144 M146 S150 Q153 K192 S194 L197 L13 G14 N17 A34 K36 M82 E83 M85 S89 Q92 K131 S133 L136
BS03 1CX A K97 V127 I141 D208 F209 L215 K36 V66 I80 D147 F148 L154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dy7, PDBe:3dy7, PDBj:3dy7
PDBsum3dy7
PubMed19019675
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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