Structure of PDB 3dy0 Chain A

Receptor sequence

>3dy0A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]

RDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGL
GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTF
VSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNA
VVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYL
LDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFK
KRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVS
EMVHKAVVEVDESGTRAAAATGTIFTF

3D structure

PDB

3dy0 The heparin binding site of protein C inhibitor is protease-dependent.

Chain

Resolution

1.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	F31 Y34 S43 Q44 N45 I46 F47 F48 S49 P50 F204 Y205 V206 E220 Y225 A244 T245 A246 L247 F248 I249 L250 P251 M256 E260 L268 R278 Q279 L280 E281 L282 Y283 P285 F287 A343 A344	F5 Y8 S17 Q18 N19 I20 F21 F22 S23 P24 F178 Y179 V180 E194 Y199 A218 T219 A220 L221 F222 I223 L224 P225 M230 E234 L242 R252 Q253 L254 E255 L256 Y257 P259 F261 A317 A318

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity

	Cellular Component
GO:0005615	extracellular space

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3dy0, PDBe:3dy0, PDBj:3dy0
PDBsum	3dy0
PubMed	18974053
UniProt	P05154\|IPSP_HUMAN Plasma serine protease inhibitor (Gene Name=SERPINA5)

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