Structure of PDB 3dwg Chain A

Receptor sequence

>3dwgA (length=325) Species: 83332 (Mycobacterium tuberculosis H37Rv)

RHMTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTG
SIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLI
CVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVM
LYQYGNPANTDSHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLRE
HVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAV
RRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGW
KYLSTGAYAGSLDDAETALEGQLWA

3D structure

• PDB: 3dwg Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
• Chain: A
• Resolution: 1.53 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K51 S265
• Catalytic site (residue number reindexed from 1): K53 S267
• Enzyme Commision number: 2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	K51 N81 G184 T185 T186 G187 T188 S265 A294 D295	K53 N83 G186 T187 T188 G189 T190 S267 A296 D297

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0005515 protein binding
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0030170 pyridoxal phosphate binding
• GO:0033847 O-phosphoserine sulfhydrylase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:3dwg, PDBe:3dwg, PDBj:3dwg
• PDBsum: 3dwg
• PubMed: 18771296
• UniProt: P9WP53|CYSM_MYCTU O-phosphoserine sulfhydrylase (Gene Name=cysM)