Structure of PDB 3dwb Chain A

Receptor sequence
>3dwbA (length=660) Species: 9606 (Homo sapiens) [Search protein sequence]
SEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFS
NLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLM
ELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNS
NVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLP
FLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVR
KTSSFLDQRFQDADEKFMEVMWKFCVSDTENNLGFALGPMFVKATFAEDS
KSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFI
MDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSM
TPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELT
HAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGF
AQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSP
MNPPHKCEVW
3D structure
PDB3dwb Structure of human endothelin-converting enzyme I complexed with phosphoramidon
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H607 E608 H611 E667 D671 H732 R738
Catalytic site (residue number reindexed from 1) H497 E498 H501 E557 D561 H622 R628
Enzyme Commision number 3.4.24.71: endothelin-converting enzyme 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H607 H611 E667 H497 H501 E557
BS02 5HD A V519 V544 Q557 V409 V434 Q447
BS03 RDF A F149 V565 N566 A567 V604 H607 E608 H611 E667 H732 R738 F49 V455 N456 A457 V494 H497 E498 H501 E557 H622 R628 MOAD: ic50=0.65uM
PDBbind-CN: -logKd/Ki=6.19,IC50=0.65uM
BindingDB: IC50=1200nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3dwb, PDBe:3dwb, PDBj:3dwb
PDBsum3dwb
PubMed18992253
UniProtP42892|ECE1_HUMAN Endothelin-converting enzyme 1 (Gene Name=ECE1)

[Back to BioLiP]