Structure of PDB 3dtg Chain A

Receptor sequence
>3dtgA (length=363) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
LEFTVSANTNPATDAVRESILANPGFGKYYTDHMVSIDYTVDEGWHNAQV
IPYGPIQLDPSAIVLHYGQEIFEGLKAYRWADGSIVSFRPEANAARLQSS
ARRLAIPELPEEVFIESLRQLIAVDEKWVPPAGGEESLYLRPFVIATEPG
LGVRPSNEYRYLLIASPAGAYFKGGIKPVSVWLSHEYVRASPGGTGAAKF
GGNYAASLLAQAQAAEMGCDQVVWLDAIERRYVEEMGGMNLFFVFGSGGS
ARLVTPELSGSLLPGITRDSLLQLATDAGFAVEERKIDVDEWQKKAGAGE
ITEVFACGTAAVITPVSHVKHHDGEFTIADGQPGEITMALRDTLTGIQRG
TFADTHGWMARLN
3D structure
PDB3dtg Structural analysis of mycobacterial branched chain aminotransferase - implications for inhibitor design
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K204
Catalytic site (residue number reindexed from 1) K199
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A R101 R194 K204 Y209 E240 G243 L268 I271 T272 T314 R96 R189 K199 Y204 E235 G238 L263 I266 T267 T309
BS02 OBZ A F77 Y176 Y209 F72 Y171 Y204
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

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Molecular Function
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Biological Process
External links
PDB RCSB:3dtg, PDBe:3dtg, PDBj:3dtg
PDBsum3dtg
PubMed
UniProtA0R066|ILVE_MYCS2 Branched-chain-amino-acid aminotransferase (Gene Name=ilvE)

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