Structure of PDB 3dsz Chain A

Receptor sequence
>3dszA (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPAPPLSKVPLQQNFQDNQFHGKWYQVGRAGNAALREDKDPQKMTAQIY
ELKEDKSYNVTAVRFRKKKCDYLTMTFVPGSQPGEFTLGNIKSYPGLTSY
LVRVVSTNYNQHAMVFFKKVSQNREYFSITLLGRTKELASELKENFIRFS
KSLGLPENHIVFPVPIDQCIDG
3D structure
PDB3dsz High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LIZ A Q33 R36 T52 Q54 V66 A68 R70 D77 L79 Y106 F123 T136 Q27 R30 T46 Q48 V60 A62 R64 D71 L73 Y100 F117 T130 MOAD: Kd=17.1nM
PDBbind-CN: -logKd/Ki=7.77,Kd=17.1nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0140315 iron ion sequestering activity
GO:1903981 enterobactin binding
Biological Process
GO:0006826 iron ion transport
GO:0006915 apoptotic process
GO:0015891 siderophore transport
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031410 cytoplasmic vesicle
GO:0035580 specific granule lumen
GO:0060205 cytoplasmic vesicle lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3dsz, PDBe:3dsz, PDBj:3dsz
PDBsum3dsz
PubMed19227970
UniProtP80188|NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (Gene Name=LCN2)

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