Structure of PDB 3dqw Chain A

Receptor sequence
>3dqwA (length=279) Species: 9031 (Gallus gallus) [Search protein sequence]
LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP
EAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEM
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD
FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE
LTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPE
ERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB3dqw Activation of tyrosine kinases by mutation of the gatekeeper threonine.
ChainA
Resolution2.017 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D132 R134 A136 N137 D150 F170
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A V281 A293 K295 I338 M341 L393 D404 V27 A39 K41 I84 M87 L139 D150
BS02 MG A N391 D404 N137 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dqw, PDBe:3dqw, PDBj:3dqw
PDBsum3dqw
PubMed18794843
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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