Structure of PDB 3dpk Chain A

Receptor sequence
>3dpkA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
VRWKIIESSYTFIDPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLG
AVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP
VLVITEYCCYGDLLNFLRRQLSSRDLLHFSSQVAQGMAFLASKNCIHRDV
AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVRLPVKWMAPESIFDCVYT
VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPK
NIYSIMQACWALEPTHRPTFQQICSFLQE
3D structure
PDB3dpk Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D778 A780 R782 N783 D796 N805
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D167 N176
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8C5 A A614 K616 E633 M637 T663 Y665 C666 G669 L785 F797 A56 K58 E75 M79 T105 Y107 C108 G111 L156 F168 MOAD: ic50=4.1nM
PDBbind-CN: -logKd/Ki=8.39,IC50=4.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3dpk, PDBe:3dpk, PDBj:3dpk
PDBsum3dpk
PubMed19193011
UniProtP07333|CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (Gene Name=CSF1R);
P11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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