Structure of PDB 3dp9 Chain A

Receptor sequence
>3dp9A (length=229) Species: 666 (Vibrio cholerae) [Search protein sequence]
KIGIIGAMQQEVAILKDLIEDVQEVNQAGCTFYSGQIQGVDVVLLQSGIG
KVSAALGTALLISQYAPDVVINTGSAGGFDASLNVGDVVISSEVRHHDAD
VTAFGYEIGQMAGQPAAFKADEKLMTVAEQALAQLPNTHAVRGLICTGDA
FVCTAERQQFIRQHFPSVVAVEMEASAIAQTCHQFKVPFVVVRAISDVAD
KESPLSFEEFLPLAAKSSSAMVLKMVELL
3D structure
PDB3dp9 Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.9: adenosylhomocysteine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BIG A I50 S76 A77 G78 F152 V153 V172 E173 M174 E175 D198 F208 I49 S75 A76 G77 F151 V152 V171 E172 M173 E174 D197 F207 MOAD: Kd=208pM
PDBbind-CN: -logKd/Ki=9.68,Kd=208pM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008782 adenosylhomocysteine nucleosidase activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3dp9, PDBe:3dp9, PDBj:3dp9
PDBsum3dp9
PubMed19270684
UniProtQ9KPI8|MTNN_VIBCH 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Gene Name=mtnN)

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