Structure of PDB 3dox Chain A

Receptor sequence
>3doxA (length=198) Species: 11706 (HIV-1 M:B_HXB2R) [Search protein sequence]
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIG
GFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
3D structure
PDB3dox X-ray structure of HIV-1 protease in situ product complex
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1025 T1026 G1027
Catalytic site (residue number reindexed from 1) D124 T125 G126
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D25 P81 D1025 G1027 A1028 D1029 D1030 I1047 G1048 G1049 I1050 D25 P81 D124 G126 A127 D128 D129 I146 G147 G148 I149
BS02 peptide A G27 A28 D29 D30 V32 I47 G48 L76 I84 D1025 I1050 G27 A28 D29 D30 V32 I47 G48 L76 I84 D124 I149
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3dox, PDBe:3dox, PDBj:3dox
PDBsum3dox
PubMed18704947
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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