Structure of PDB 3dlh Chain A

Receptor sequence

>3dlhA (length=673) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]

HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRK
PIPHLTGLLVPVLTLEDLHESLALSLPWEERRRRTREIASWIGRRLGLGT
PEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQ
GWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQA
VLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLL
AKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGGHLLWTLPE
RIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALA
REGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRG
TPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRL
VKEVGRLGIRHLKEVDREKLFFV

3D structure

PDB

3dlh Structure of the guide-strand-containing argonaute silencing complex.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	M82 A170 Y171 R172 I173 Y197 W202 L217 Y226 H227 R232 I254 P255 H256 V264 L265 T266 L267 L279 S280 L281 R286 M413 W415 K422 I434 L435 N436 H445 R446 N449 G481 R548 R580 D609 T613 P614 R615 Y642 S645 R651 H657 R661 V685	M80 A168 Y169 R170 I171 Y195 W200 L215 Y224 H225 R230 I252 P253 H254 V262 L263 T264 L265 L274 S275 L276 R281 M408 W410 K417 I429 L430 N431 H440 R441 N444 G476 R536 R568 D597 T601 P602 R603 Y630 S633 R639 H645 R649 V673
BS02	MG	A	Q342 G459	Q337 G454

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004520	DNA endonuclease activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0006260	DNA replication
GO:0044355	clearance of foreign intracellular DNA

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3dlh, PDBe:3dlh, PDBj:3dlh
PDBsum	3dlh
PubMed	18754009
UniProt	Q746M7\|AGO_THET2 Protein argonaute (Gene Name=ago)

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